Amikacin Sulfate
Also known as: Amikin, Amiglyde-V, Amikin Pediatric
CAS Number: 39831-55-5
Aminoglycoside antibiotic — resistant gram-negative coverage
Pharmacopeia Standards
Mechanism of Action
Semi-synthetic aminoglycoside derived from kanamycin A; amide modification at position 1 confers resistance to most aminoglycoside-modifying enzymes (AMEs). Binds 30S ribosomal subunit (16S rRNA, A-site). Bactericidal concentration-dependent killing. Active against strains resistant to gentamicin and tobramycin through AME-mediated mechanisms. Retains activity against most Enterobacteriaceae, Pseudomonas, Acinetobacter (aminoglycoside-sensitive).
Technical Specifications
| Generic / INN Name | Amikacin Sulfate |
| CAS Registry Number | 39831-55-5 |
| Molecular Formula | C22H43N5O13·2H2SO4 |
| Molecular Weight | 781.76 g/mol |
| Typical Purity | 97.0–103.0% (on anhydrous sulfate basis) |
| Storage Conditions | Store below 25°C |
| Shelf Life | 24 months from date of manufacture |
| Category | Aminoglycosides |
Specifications are indicative and intended for sourcing reference only. Always confirm against the supplier's Certificate of Analysis and the applicable pharmacopeial monograph before issuing a purchase specification.
Typical Applications
MDR gram-negative infections resistant to gentamicin/tobramycin, serious nosocomial infections (P. aeruginosa, Acinetobacter baumannii, K. pneumoniae), NDR-TB treatment protocols (key second-line injectable drug), complicated UTIs, bacteremia in immunocompromised patients.
Manufacturers (0+)
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