Amoxicillin Sodium
Also known as: Amoxil IV, Augmentin IV (with clavulanate), Clamoxyl IV
CAS Number: 34642-77-8
Aminopenicillin (Beta-Lactam), Parenteral Salt
Pharmacopeia Standards
Mechanism of Action
Amoxicillin binds penicillin-binding proteins 1a, 1b and 3, inhibiting the transpeptidase reaction that cross-links peptidoglycan chains in the bacterial cell wall. The para-hydroxy group on the phenylglycine side chain extends the spectrum beyond benzylpenicillin to include many Enterobacterales, Haemophilus influenzae and Helicobacter pylori. It is readily hydrolysed by class A beta-lactamases, which is why it is so often co-formulated with clavulanate potassium.
Technical Specifications
| Generic / INN Name | Amoxicillin Sodium |
| CAS Registry Number | 34642-77-8 |
| Molecular Formula | C16H18N3NaO5S |
| Molecular Weight | 387.40 g/mol g/mol |
| Typical Purity | NLT 89.0% amoxicillin on the anhydrous basis; sterile grade endotoxin NMT 0.25 IU/mg |
| Storage Conditions | Store below 25 C in tight, light-resistant containers; the sodium salt is markedly hygroscopic and requires controlled-humidity handling. |
| Shelf Life | 24 months for sterile grade in original sealed packaging |
| Category | Penicillins |
Specifications are indicative and intended for sourcing reference only. Always confirm against the supplier's Certificate of Analysis and the applicable pharmacopeial monograph before issuing a purchase specification.
Typical Applications
Sterile powder for injection and infusion; co-packaged and co-blended amoxicillin-clavulanate injections at 5:1 and 10:1 ratios; veterinary injectable products.
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