Bacitracin Zinc
Also known as: Baciguent, Neosporin and Polysporin components, BMD, Albac, Bacivet
CAS Number: 1405-89-6
Cyclic polypeptide antibacterial
Pharmacopeia Standards
Mechanism of Action
Bacitracin binds the lipid carrier undecaprenyl pyrophosphate and blocks its dephosphorylation, halting the recycling step that regenerates the carrier needed to ferry peptidoglycan subunits across the membrane. Cell wall synthesis stops and Gram-positive organisms are killed. Zinc complexation stabilises the peptide against degradation and enhances antibacterial potency, which is why the zinc salt rather than the free base is used in nearly all commercial products.
Technical Specifications
| Generic / INN Name | Bacitracin Zinc |
| CAS Registry Number | 1405-89-6 |
| Molecular Formula | C66H101N17O16SZn (bacitracin A zinc complex) |
| Molecular Weight | 1486.07 g/mol (bacitracin A zinc complex); multi-component mixture g/mol |
| Typical Purity | NLT 65 bacitracin units per mg on dried basis (USP); zinc content 4.0-6.0% |
| Storage Conditions | Store at 2-8 C in tight, light-resistant containers; hygroscopic and heat sensitive, protect from moisture |
| Shelf Life | 24-36 months from date of manufacture under refrigerated storage |
| Category | Veterinary Antibiotics |
Specifications are indicative and intended for sourcing reference only. Always confirm against the supplier's Certificate of Analysis and the applicable pharmacopeial monograph before issuing a purchase specification.
Typical Applications
Topical ointments, creams and first-aid antibiotic combinations for human use; ophthalmic ointments; and as bacitracin methylene disalicylate or zinc feed premix for growth promotion and necrotic enteritis control in poultry and swine in markets that permit it.
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