Benzathine Benzylpenicillin
Also known as: Bicillin L-A, Extencilline, Penidure, Pendysin
CAS Number: 1538-09-6
Long-Acting Depot Penicillin (Beta-Lactam)
Pharmacopeia Standards
Mechanism of Action
The dibenzylethylenediamine salt is a poorly soluble depot form that hydrolyses slowly at the intramuscular injection site to liberate benzylpenicillin over two to four weeks. The released benzylpenicillin binds penicillin-binding proteins and blocks peptidoglycan transpeptidation. Sustained low plasma concentrations are sufficient for organisms that have never developed penicillin resistance, notably Treponema pallidum and Streptococcus pyogenes.
Technical Specifications
| Generic / INN Name | Benzathine Benzylpenicillin |
| CAS Registry Number | 1538-09-6 |
| Molecular Formula | C48H56N6O8S2 |
| Molecular Weight | 909.13 g/mol g/mol |
| Typical Purity | NLT 96.0% and NMT 102.0% of total penicillins (anhydrous basis); benzathine content 24.0-27.0% |
| Storage Conditions | Store below 25 C in tight, light-resistant containers protected from moisture; sterile grade handled under Grade A/B conditions with nitrogen blanketing. |
| Shelf Life | 24 months for sterile grade when stored in original sealed packaging |
| Category | Penicillins |
Specifications are indicative and intended for sourcing reference only. Always confirm against the supplier's Certificate of Analysis and the applicable pharmacopeial monograph before issuing a purchase specification.
Typical Applications
Sterile aqueous suspension for injection (0.6 MIU, 1.2 MIU, 2.4 MIU); fixed combinations with procaine benzylpenicillin; secondary prophylaxis programmes for rheumatic heart disease.
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