Benzylpenicillin Sodium
Also known as: Crystapen, Pfizerpen, Benzylpenicillin Sodium for Injection
CAS Number: 69-57-8
Natural Penicillin Antibiotic (Beta-Lactam)
Pharmacopeia Standards
Mechanism of Action
Benzylpenicillin acylates the transpeptidase domain of penicillin-binding proteins, halting the cross-linking of peptidoglycan strands in the bacterial cell wall. The resulting weakened murein sacculus cannot withstand internal osmotic pressure, and autolysin activity completes lysis. Activity is concentrated against streptococci, meningococci, Treponema pallidum and non-beta-lactamase-producing anaerobes.
Technical Specifications
| Generic / INN Name | Benzylpenicillin Sodium |
| CAS Registry Number | 69-57-8 |
| Molecular Formula | C16H17N2NaO4S |
| Molecular Weight | 356.37 g/mol g/mol |
| Typical Purity | NLT 96.0% and NMT 102.0% (anhydrous basis); sterile grade endotoxin NMT 0.01 IU/mg |
| Storage Conditions | Store in tight, light-resistant containers below 25 C, protected from moisture; sterile grade under nitrogen headspace in double LDPE liners within HDPE drums. |
| Shelf Life | 36 months for non-sterile grade; 24 months for sterile crystalline grade when stored as directed |
| Category | Penicillins |
Specifications are indicative and intended for sourcing reference only. Always confirm against the supplier's Certificate of Analysis and the applicable pharmacopeial monograph before issuing a purchase specification.
Typical Applications
Sterile crystalline API for lyophilised and dry-powder-filled vials (1 MIU, 5 MIU, 10 MIU); veterinary intramammary and injectable formulations; reference standard and susceptibility disc manufacture.
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