Butenafine Hydrochloride
Also known as: Mentax, Lotrimin Ultra, Butop, Fintop, Volley, Butenafin
CAS Number: 101827-46-7
Benzylamine antifungal — topical
Pharmacopeia Standards
Mechanism of Action
Butenafine is a benzylamine that inhibits squalene epoxidase, the same target as the allylamines, blocking ergosterol synthesis while causing intracellular squalene to accumulate to toxic concentrations. The squalene accumulation is fungicidal against dermatophytes rather than merely growth-arresting. Its high lipophilicity produces prolonged retention in the stratum corneum, supporting short treatment courses.
Technical Specifications
| Generic / INN Name | Butenafine Hydrochloride |
| CAS Registry Number | 101827-46-7 |
| Molecular Formula | C23H27N·HCl |
| Molecular Weight | 353.93 g/mol |
| Typical Purity | 98.5–101.0% (on dried basis) |
| Storage Conditions | Store below 25°C in tightly closed, light-resistant containers in a dry place; protect from light |
| Shelf Life | 48 months from date of manufacture |
| Category | Antifungals |
Specifications are indicative and intended for sourcing reference only. Always confirm against the supplier's Certificate of Analysis and the applicable pharmacopeial monograph before issuing a purchase specification.
Typical Applications
Tinea pedis interdigitalis, tinea cruris, tinea corporis, pityriasis versicolor, cutaneous candidiasis
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