Cefotaxime Sodium

Also known as: Claforan, Taxim, Cefotax, Biotax

CAS Number: 64485-93-4

3rd generation cephalosporin — parenteral

Pharmacopeia Standards

USPEPBP

Mechanism of Action

First third-generation cephalosporin introduced clinically. Binds PBP-1a, PBP-1b, PBP-3. Excellent activity against Enterobacteriaceae, H. influenzae, N. gonorrhoeae, S. pneumoniae. Metabolized in vivo to desacetylcefotaxime (active metabolite with additive effects). Stable to many beta-lactamases.

Technical Specifications

Generic / INN Name	Cefotaxime Sodium
CAS Registry Number	64485-93-4
Molecular Formula	C16H16N5NaO7S2
Molecular Weight	477.45 g/mol
Typical Purity	97.0–103.0%
Storage Conditions	Store at room temperature below 25°C, protect from light
Shelf Life	24 months from date of manufacture
Category	Cephalosporins

Specifications are indicative and intended for sourcing reference only. Always confirm against the supplier's Certificate of Analysis and the applicable pharmacopeial monograph before issuing a purchase specification.

Typical Applications

Bacterial meningitis (first-line in neonates and children), septicemia, serious respiratory/urinary/gynecological infections, gonococcal infections, Lyme disease (neurological), surgical prophylaxis, intra-abdominal infections.