Cefpodoxime Proxetil

Also known as: Vantin, Orelox, Banan, Cefpodox, Monocef-O

CAS Number: 87239-81-4

Third-Generation Oral Cephalosporin Prodrug (Beta-Lactam)

Pharmacopeia Standards

USPBPEPIPJP

Mechanism of Action

Cefpodoxime proxetil is an orally absorbed ester prodrug that is de-esterified by intestinal esterases to release active cefpodoxime. Cefpodoxime binds penicillin-binding protein 3 with high affinity, blocking septal peptidoglycan cross-linking and causing filamentation and lysis. The aminothiazolyl methoxyimino side chain confers substantial stability against many common beta-lactamases and extends the Gram-negative spectrum.

Technical Specifications

Generic / INN Name	Cefpodoxime Proxetil
CAS Registry Number	87239-81-4
Molecular Formula	C21H27N5O9S2
Molecular Weight	557.60 g/mol g/mol
Typical Purity	NLT 93.0% and NMT 102.0% on the anhydrous, solvent-free basis; total impurities NMT 3.0%
Storage Conditions	Store at 2-8 C in tight, light-resistant containers under nitrogen; strongly hygroscopic and sensitive to heat and humidity.
Shelf Life	24 months under refrigerated storage in original sealed packaging
Category	Cephalosporins

Specifications are indicative and intended for sourcing reference only. Always confirm against the supplier's Certificate of Analysis and the applicable pharmacopeial monograph before issuing a purchase specification.

Typical Applications

Oral film-coated tablets, dispersible tablets and powder for oral suspension; fixed-dose combinations with clavulanate potassium widely marketed in India; paediatric taste-masked granules.