Cefprozil
Also known as: Cefzil, Procef, Arzomicin, Refzil-O
CAS Number: 92665-29-7
Second-Generation Oral Cephalosporin (Beta-Lactam)
Pharmacopeia Standards
Mechanism of Action
Cefprozil acylates penicillin-binding proteins and prevents the transpeptidation step of peptidoglycan cross-linking, leading to cell wall failure. The propenyl group at the 3-position improves oral absorption and half-life relative to cefaclor while retaining second-generation Gram-negative coverage. It is marketed as a mixture of cis and trans isomers in a defined ratio, with the cis isomer predominating.
Technical Specifications
| Generic / INN Name | Cefprozil |
| CAS Registry Number | 92665-29-7 |
| Molecular Formula | C18H19N3O5S |
| Molecular Weight | 389.43 g/mol (anhydrous); 407.44 g/mol (monohydrate) g/mol |
| Typical Purity | NLT 90.0% and NMT 102.0% on the anhydrous basis; cis isomer content NLT 90.0% of total cefprozil |
| Storage Conditions | Store below 25 C in tight, light-resistant containers; protect from moisture and heat. |
| Shelf Life | 36 months in original sealed packaging when stored as directed |
| Category | Cephalosporins |
Specifications are indicative and intended for sourcing reference only. Always confirm against the supplier's Certificate of Analysis and the applicable pharmacopeial monograph before issuing a purchase specification.
Typical Applications
Oral tablets, film-coated tablets and powder for oral suspension; paediatric pharyngitis, otitis media and sinusitis products; twice-daily respiratory infection lines.
Manufacturers (1+)
View all →India
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