Ceftiofur Sodium
Also known as: Naxcel, Excenel, Excede, Ceftiocyl, Ceftiomax
CAS Number: 104010-37-9
Third-generation veterinary cephalosporin
Pharmacopeia Standards
Mechanism of Action
Ceftiofur is a third-generation cephalosporin that binds penicillin-binding proteins and blocks the transpeptidation step of peptidoglycan cross-linking, causing cell wall failure and lysis in dividing bacteria. Its aminothiazolyl methoxyimino side chain confers stability against many Gram-negative beta-lactamases and a broad spectrum covering the major bovine, porcine and avian respiratory pathogens. It is rapidly metabolised in the animal to desfuroylceftiofur, which retains antibacterial activity.
Technical Specifications
| Generic / INN Name | Ceftiofur Sodium |
| CAS Registry Number | 104010-37-9 |
| Molecular Formula | C19H16N5NaO7S3 |
| Molecular Weight | 545.54 g/mol g/mol |
| Typical Purity | NLT 800 mcg ceftiofur per mg on anhydrous basis (USP); endotoxin NMT 0.15 EU/mg for sterile grade |
| Storage Conditions | Store at 2-8 C in tightly sealed, light-resistant containers under nitrogen; maintain cold chain in transit |
| Shelf Life | 24 months from date of manufacture under refrigerated storage |
| Category | Veterinary Antibiotics |
Specifications are indicative and intended for sourcing reference only. Always confirm against the supplier's Certificate of Analysis and the applicable pharmacopeial monograph before issuing a purchase specification.
Typical Applications
Sterile powder and suspension for injection in cattle, swine, sheep, goats, horses, day-old chicks and turkey poults; treatment of bovine respiratory disease, foot rot, metritis and swine respiratory disease.
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