Ceftriaxone Sodium

Also known as: Rocephin, Oframax, Monocef, Ceftron, Longacef

CAS Number: 104376-79-6

3rd generation cephalosporin — parenteral

Pharmacopeia Standards

USPBPEP

Mechanism of Action

Third-generation parenteral cephalosporin with exceptional stability against a broad range of beta-lactamases. Binds PBP-1a, PBP-1b, PBP-3. Active against Neisseria meningitidis, H. influenzae, most Enterobacteriaceae, Streptococcus pneumoniae. Long half-life (~8 hours) enables once-daily dosing. High protein binding (~95%) contributes to prolonged serum levels.

Technical Specifications

Generic / INN Name	Ceftriaxone Sodium
CAS Registry Number	104376-79-6
Molecular Formula	C18H16N8Na2O7S3
Molecular Weight	661.60 g/mol
Typical Purity	97.0–102.0%
Storage Conditions	Store below 25°C, protected from light; reconstituted solutions: use immediately or refrigerate up to 24h
Shelf Life	24 months from date of manufacture
Category	Cephalosporins

Specifications are indicative and intended for sourcing reference only. Always confirm against the supplier's Certificate of Analysis and the applicable pharmacopeial monograph before issuing a purchase specification.

Typical Applications

Bacterial meningitis (first-line, IV), community-acquired pneumonia (moderate-severe, IV/IM), gonorrhea (first-line, single IM dose 500mg), typhoid fever (alternative to fluoroquinolones), surgical prophylaxis, Lyme disease (neurological/cardiac manifestations), pyelonephritis, septicemia, intra-abdominal infections.