Cefuroxime Axetil

Also known as: Ceftin, Zinnat, Cefurax, Supacef, Altacef

CAS Number: 64544-07-6

2nd generation cephalosporin — oral prodrug

Pharmacopeia Standards

USPEP

Mechanism of Action

Prodrug ester of cefuroxime (active moiety). Hydrolyzed by intestinal esterases to cefuroxime after absorption. Inhibits bacterial cell wall synthesis by binding PBPs. Second-generation spectrum: superior H. influenzae coverage (including beta-lactamase-producing strains), Moraxella catarrhalis, S. pneumoniae, MSSA.

Technical Specifications

Generic / INN Name	Cefuroxime Axetil
CAS Registry Number	64544-07-6
Molecular Formula	C20H22N4O10S
Molecular Weight	510.47 g/mol
Typical Purity	97.0–103.0%
Storage Conditions	Store below 25°C in a dry place
Shelf Life	36 months from date of manufacture
Category	Cephalosporins

Specifications are indicative and intended for sourcing reference only. Always confirm against the supplier's Certificate of Analysis and the applicable pharmacopeial monograph before issuing a purchase specification.

Typical Applications

Community-acquired pneumonia (mild-moderate), acute bacterial sinusitis, acute otitis media, pharyngitis/tonsillitis, urinary tract infections (including cystitis), acute exacerbations of chronic bronchitis, uncomplicated gonorrhea (alternative), early Lyme disease.