Chloroquine Phosphate
Also known as: Aralen, Resochin, Lariago, Nivaquine, Malarivon, Emquin
CAS Number: 50-63-5
Antimalarial (4-Aminoquinoline)
Pharmacopeia Standards
Mechanism of Action
Chloroquine is a weak base that concentrates several thousand-fold in the acidic digestive vacuole of the malaria parasite. There it binds ferriprotoporphyrin IX and prevents its polymerisation into inert haemozoin, so free haem and chloroquine-haem complexes accumulate and lyse parasite membranes. Resistance in Plasmodium falciparum arises chiefly from mutations in the PfCRT transporter that pump the drug out of the vacuole.
Technical Specifications
| Generic / INN Name | Chloroquine Phosphate |
| CAS Registry Number | 50-63-5 |
| Molecular Formula | C18H26ClN3 · 2H3PO4 |
| Molecular Weight | 515.86 g/mol g/mol |
| Typical Purity | Not less than 98.5% (assay), on the dried basis |
| Storage Conditions | Store in well-closed containers below 30°C; protect from light |
| Shelf Life | 60 months in original sealed packaging |
| Category | Antimalarials |
Specifications are indicative and intended for sourcing reference only. Always confirm against the supplier's Certificate of Analysis and the applicable pharmacopeial monograph before issuing a purchase specification.
Typical Applications
Tablets and syrups for Plasmodium vivax malaria and for extraintestinal amoebiasis; anti-inflammatory use in rheumatology; veterinary and aquaculture applications.
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