Ciprofloxacin Hydrochloride

Also known as: Cipro, Ciflox, Cifran, Baycip, Ciprolet

CAS Number: 86393-32-0

Fluoroquinolone — DNA gyrase and topoisomerase IV inhibitor

Pharmacopeia Standards

USPBPIPEP

Mechanism of Action

Second-generation fluoroquinolone that inhibits bacterial DNA gyrase (topoisomerase II — primary target in gram-negatives) and topoisomerase IV (primary target in gram-positives), preventing DNA supercoiling resolution and chromosome segregation. Bactericidal with concentration-dependent killing kinetics. Excellent intracellular penetration. Active against most gram-negative aerobes; limited Streptococcal activity.

Technical Specifications

Generic / INN Name	Ciprofloxacin Hydrochloride
CAS Registry Number	86393-32-0
Molecular Formula	C17H19FN3O3·HCl
Molecular Weight	367.81 g/mol
Typical Purity	98.0–102.0% (anhydrous basis)
Storage Conditions	Store below 25°C, protected from light
Shelf Life	36 months from date of manufacture
Category	Fluoroquinolones

Specifications are indicative and intended for sourcing reference only. Always confirm against the supplier's Certificate of Analysis and the applicable pharmacopeial monograph before issuing a purchase specification.

Typical Applications

Urinary tract infections (complicated and uncomplicated), pyelonephritis (first-line in many guidelines), typhoid/enteric fever, respiratory infections (non-pneumococcal), complicated intra-abdominal infections (with metronidazole), anthrax post-exposure prophylaxis and treatment (first-line), prostatitis (chronic bacterial), gonorrhea (high-resistance — check local guidelines), bone/joint infections, traveler's diarrhea, nosocomial gram-negative infections.