Clavulanate Potassium
Also known as: Augmentin (with amoxicillin), Timentin (with ticarcillin), Clavulin, Co-amoxiclav
CAS Number: 61177-45-5
Beta-Lactamase Inhibitor (Clavam)
Pharmacopeia Standards
Mechanism of Action
Clavulanic acid is a suicide substrate that binds the serine residue in the active site of class A beta-lactamases and undergoes ring opening to form an irreversibly acylated enzyme. This permanent inactivation protects the partner penicillin from hydrolysis, restoring its activity against beta-lactamase-producing organisms. Its own intrinsic antibacterial activity is negligible, so it is never used alone.
Technical Specifications
| Generic / INN Name | Clavulanate Potassium |
| CAS Registry Number | 61177-45-5 |
| Molecular Formula | C8H8KNO5 |
| Molecular Weight | 237.25 g/mol g/mol |
| Typical Purity | NLT 96.5% and NMT 102.0% on the anhydrous basis for neat API; blended grades assayed to the declared clavulanic acid content |
| Storage Conditions | Store at 2-8 C in hermetically sealed, moisture-proof containers with desiccant under nitrogen; extremely hygroscopic and must be handled at low relative humidity. |
| Shelf Life | 24 months for neat API and 18-24 months for co-processed blends under refrigerated storage |
| Category | Beta-Lactamase Inhibitors |
Specifications are indicative and intended for sourcing reference only. Always confirm against the supplier's Certificate of Analysis and the applicable pharmacopeial monograph before issuing a purchase specification.
Typical Applications
Amoxicillin-clavulanate oral tablets, dispersible tablets and suspensions at 4:1, 7:1, 8:1, 14:1 and 16:1 ratios; 2:1 injectable co-blends; ticarcillin-clavulanate infusion products; co-processed 1:1 clavulanate with microcrystalline cellulose or syloid.
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