Clindamycin Hydrochloride
Also known as: Cleocin, Dalacin, Clindahexal, Evoclin
CAS Number: 21462-39-5
Lincosamide antibiotic — skin, soft tissue, and anaerobic infections
Pharmacopeia Standards
Mechanism of Action
Lincosamide antibiotic that binds the same 50S ribosomal subunit site as macrolides (23S rRNA — domain V), inhibiting protein translocation. Bacteriostatic at usual concentrations. Spectrum: aerobic gram-positive cocci (MSSA, S. pyogenes, viridans streptococci, S. pneumoniae) and anaerobes (Bacteroides fragilis, Peptostreptococcus, Fusobacterium). No activity against gram-negative aerobes (permeability barrier). Active against many community-MRSA (CA-MRSA) strains depending on inducible resistance (D-test required).
Technical Specifications
| Generic / INN Name | Clindamycin Hydrochloride |
| CAS Registry Number | 21462-39-5 |
| Molecular Formula | C18H33ClN2O5S·HCl |
| Molecular Weight | 461.44 g/mol |
| Typical Purity | 98.0–102.0% (on anhydrous basis) |
| Storage Conditions | Store below 25°C in a dry place |
| Shelf Life | 24 months from date of manufacture |
| Category | Lincosamides |
Specifications are indicative and intended for sourcing reference only. Always confirm against the supplier's Certificate of Analysis and the applicable pharmacopeial monograph before issuing a purchase specification.
Typical Applications
Skin and soft tissue infections (SSTIs), including CA-MRSA, cellulitis, abscesses, bone and joint infections (osteomyelitis — excellent bone penetration), intra-abdominal and pelvic infections (with gram-negative coverage), aspiration pneumonia and lung abscess, malaria (with quinine or primaquine), acne (topical gel/solution), bacterial vaginosis (topical vaginal cream), toxin suppression in streptococcal and staphylococcal toxic shock syndrome.
Manufacturers (1+)
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