Clindamycin Phosphate
Also known as: Cleocin, Dalacin, Clindac A, Clinda-Derm, Evoclin, Clindesse
CAS Number: 24729-96-2
Lincosamide Antibacterial
Pharmacopeia Standards
Mechanism of Action
Clindamycin phosphate is an inactive prodrug hydrolysed in vivo by alkaline phosphatases to clindamycin, which binds the 50S ribosomal subunit at the peptidyl transferase centre and blocks peptide bond formation. It also suppresses bacterial toxin synthesis at sub-inhibitory concentrations, which is the basis of its use in toxin-mediated infections. Activity spans Gram-positive cocci, anaerobes and Propionibacterium acnes.
Technical Specifications
| Generic / INN Name | Clindamycin Phosphate |
| CAS Registry Number | 24729-96-2 |
| Molecular Formula | C18H34ClN2O8PS |
| Molecular Weight | 504.96 g/mol g/mol |
| Typical Purity | 758-807 micrograms of clindamycin per mg on the anhydrous basis (USP); clindamycin B phosphate NMT 4.0%; free clindamycin NMT 1.5% |
| Storage Conditions | Store below 25 degrees C in airtight light-resistant containers protected from moisture; sterile grade under validated aseptic conditions |
| Shelf Life | 48 months from date of manufacture |
| Category | Lincosamides |
Specifications are indicative and intended for sourcing reference only. Always confirm against the supplier's Certificate of Analysis and the applicable pharmacopeial monograph before issuing a purchase specification.
Typical Applications
Sterile solutions for intravenous and intramuscular injection, topical gels, solutions, lotions and foams for acne, vaginal creams and suppositories, and fixed-dose topical combinations with benzoyl peroxide, adapalene or tretinoin.
Manufacturers (1+)
View all →India
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