Clotrimazole
Also known as: Canesten, Candid, Lotrimin, Mycelex, Clocip, Surfaz
CAS Number: 23593-75-1
Imidazole antifungal — topical
Pharmacopeia Standards
Mechanism of Action
Clotrimazole binds fungal cytochrome P450 14-alpha-demethylase and blocks ergosterol biosynthesis, increasing membrane permeability and causing leakage of intracellular potassium and phosphorus. At higher topical concentrations it acts directly on the membrane and inhibits fungal peroxidases, producing a fungicidal effect. It also has useful activity against Corynebacterium minutissimum and Trichomonas.
Technical Specifications
| Generic / INN Name | Clotrimazole |
| CAS Registry Number | 23593-75-1 |
| Molecular Formula | C22H17ClN2 |
| Molecular Weight | 344.84 g/mol |
| Typical Purity | 98.5–100.5% (on dried basis) |
| Storage Conditions | Store below 25°C in tightly closed containers in a dry place; protect from light |
| Shelf Life | 60 months from date of manufacture |
| Category | Antifungals |
Specifications are indicative and intended for sourcing reference only. Always confirm against the supplier's Certificate of Analysis and the applicable pharmacopeial monograph before issuing a purchase specification.
Typical Applications
Tinea pedis, cruris and corporis, cutaneous and vulvovaginal candidiasis, pityriasis versicolor, oropharyngeal candidiasis as troche, erythrasma, otomycosis
Manufacturers (0+)
View all →Do you manufacture Clotrimazole? Add your free listing and reach global buyers.
Add listing — FreeCan you supply Clotrimazole? List as an authorised distributor or export house.
Register as traderEarn commission by connecting buyers with verified API suppliers. Free to join.
Become an agent