Contezolid
Also known as: Youxitai, MRX-I
CAS Number: 1112968-42-9
Oxazolidinone antibacterial
Mechanism of Action
Contezolid binds the peptidyl transferase centre of the 50S ribosomal subunit and blocks formation of the 70S initiation complex, inhibiting bacterial protein synthesis at initiation in the same way as linezolid. A 2,3-dihydropyridin-4-one replaces the acetamide-bearing morpholine of earlier oxazolidinones, which markedly reduces monoamine oxidase inhibition and the myelosuppression associated with prolonged linezolid therapy. Activity is directed at resistant Gram-positive pathogens including MRSA, VRE and penicillin-resistant pneumococci.
Technical Specifications
| Generic / INN Name | Contezolid |
| CAS Registry Number | 1112968-42-9 |
| Molecular Formula | C18H15F3N4O4 |
| Molecular Weight | 408.33 g/mol g/mol |
| Typical Purity | NLT 98.0% by HPLC; chiral purity NLT 99.0%; single impurity NMT 0.15% |
| Storage Conditions | Store at 2-8 C, protected from light and moisture in sealed containers |
| Shelf Life | 24 months from date of manufacture under recommended storage |
| Category | Oxazolidinones |
Specifications are indicative and intended for sourcing reference only. Always confirm against the supplier's Certificate of Analysis and the applicable pharmacopeial monograph before issuing a purchase specification.
Typical Applications
Oral tablets for complicated skin and soft tissue infection caused by resistant Gram-positive bacteria, with a prodrug intravenous form, contezolid acefosamil, in later-stage development for bone, joint and diabetic foot infection.
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