Cycloserine
Also known as: Coxerin, Seromycin, Cycloser, Myser, Closerin
CAS Number: 68-41-7
Antitubercular (Second-Line Cell Wall Inhibitor)
Pharmacopeia Standards
Mechanism of Action
Cycloserine is a structural analogue of D-alanine that competitively inhibits alanine racemase (Alr) and D-alanine:D-alanine ligase (Ddl). Blocking these enzymes prevents formation of the D-alanyl-D-alanine dipeptide required for peptidoglycan cross-linking. The result is a defective cell wall and bacteriostatic activity against Mycobacterium tuberculosis, with no cross-resistance to other antitubercular classes.
Technical Specifications
| Generic / INN Name | Cycloserine |
| CAS Registry Number | 68-41-7 |
| Molecular Formula | C3H6N2O2 |
| Molecular Weight | 102.09 g/mol g/mol |
| Typical Purity | Not less than 90.0% (USP assay, on anhydrous basis) |
| Storage Conditions | Store at 2-8 degrees C in tightly closed, moisture-proof containers; hygroscopic and heat labile, protect from light and humidity |
| Shelf Life | 24 months from date of manufacture when stored refrigerated as directed |
| Category | Anti-Tubercular Agents |
Specifications are indicative and intended for sourcing reference only. Always confirm against the supplier's Certificate of Analysis and the applicable pharmacopeial monograph before issuing a purchase specification.
Typical Applications
Bulk API for 250 mg cycloserine capsules and dispersible paediatric formulations used in longer regimens for multidrug-resistant tuberculosis, and as a component of WHO Group B and C oral regimen combinations.
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