Demeclocycline Hydrochloride
Also known as: Declomycin, Ledermycin, Detravis
CAS Number: 64-73-3
Tetracycline Antibacterial
Pharmacopeia Standards
Mechanism of Action
Demeclocycline binds the 30S ribosomal subunit and blocks aminoacyl-tRNA association with the A site, giving bacteriostatic inhibition of protein synthesis. Independently of its antibacterial action it antagonises vasopressin activity at the renal collecting duct, which is the basis of its non-antibacterial nephrology use. The 7-chloro, 6-demethyl structure gives a longer half-life than tetracycline.
Technical Specifications
| Generic / INN Name | Demeclocycline Hydrochloride |
| CAS Registry Number | 64-73-3 |
| Molecular Formula | C21H21ClN2O8 . HCl |
| Molecular Weight | 501.31 g/mol g/mol |
| Typical Purity | NLT 890 micrograms of demeclocycline per mg on the anhydrous basis (USP); chlortetracycline NMT 2.0% |
| Storage Conditions | Store below 25 degrees C in airtight light-resistant containers protected from moisture |
| Shelf Life | 36 months from date of manufacture |
| Category | Tetracyclines |
Specifications are indicative and intended for sourcing reference only. Always confirm against the supplier's Certificate of Analysis and the applicable pharmacopeial monograph before issuing a purchase specification.
Typical Applications
Oral tablets and capsules. Also an intermediate feedstock, since demeclocycline is a chemical precursor in some minocycline manufacturing routes.
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