Dihydroartemisinin
Also known as: Eurartesim (with piperaquine), Duo-Cotecxin, Artenimol, Cotecxin
CAS Number: 71939-50-9
Antimalarial (Artemisinin Derivative)
Pharmacopeia Standards
Mechanism of Action
Dihydroartemisinin is the common active metabolite of artemether, artesunate and artemisinin itself, and carries the same activating endoperoxide bridge. Iron-mediated cleavage yields alkylating free radicals that damage parasite proteins, membranes and haem detoxification machinery. It is the most potent member of the class on a molar basis and acts across asexual blood stages and young gametocytes.
Technical Specifications
| Generic / INN Name | Dihydroartemisinin |
| CAS Registry Number | 71939-50-9 |
| Molecular Formula | C15H24O5 |
| Molecular Weight | 284.35 g/mol g/mol |
| Typical Purity | Not less than 98.0% (HPLC), sum of alpha and beta anomers |
| Storage Conditions | Store in tight, light-resistant containers at 2–8°C or below 25°C as qualified; protect from moisture and heat |
| Shelf Life | 24 months in original sealed packaging under recommended conditions |
| Category | Antimalarials |
Specifications are indicative and intended for sourcing reference only. Always confirm against the supplier's Certificate of Analysis and the applicable pharmacopeial monograph before issuing a purchase specification.
Typical Applications
Fixed-dose dihydroartemisinin-piperaquine tablets; synthetic intermediate for artemether and artesunate manufacture; reference standard use.
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