Doxycycline Hyclate

Also known as: Vibramycin, Doryx, Oracea, Atridox, Periostat

CAS Number: 24390-14-5

Tetracycline antibiotic — broad-spectrum bacteriostatic

Pharmacopeia Standards

USPBPIP

Mechanism of Action

Semi-synthetic tetracycline that reversibly binds the 30S ribosomal subunit (A-site), blocking aminoacyl-tRNA binding to the mRNA–ribosome complex, thereby inhibiting protein synthesis. Bacteriostatic. Active against a uniquely broad range: aerobic gram-positives/negatives, atypical organisms (Rickettsia, Chlamydia, Mycoplasma, Borrelia), spirochetes, some protozoa (Plasmodium), and mycobacteria.

Technical Specifications

Generic / INN Name	Doxycycline Hyclate
CAS Registry Number	24390-14-5
Molecular Formula	C22H24N2O8·HCl·0.5C2H6O·0.5H2O
Molecular Weight	512.94 g/mol
Typical Purity	98.0–102.0% (on anhydrous basis)
Storage Conditions	Store below 25°C in a dry place, protected from light
Shelf Life	24 months from date of manufacture
Category	Tetracyclines

Specifications are indicative and intended for sourcing reference only. Always confirm against the supplier's Certificate of Analysis and the applicable pharmacopeial monograph before issuing a purchase specification.

Typical Applications

Atypical pneumonia (Mycoplasma, Chlamydophila, Legionella), Lyme disease (first-line — all stages), acne vulgaris (systemic, long-term suppressive), rosacea (Oracea — sub-antimicrobial 40mg), malaria prophylaxis and treatment, brucellosis (with gentamicin or rifampicin), cholera, MRSA SSTI (in combination), chlamydial/gonococcal infections (alternative), Rocky Mountain spotted fever (first-line — any age), anthrax, periodontal disease (Atridox, Periostat).