Emtricitabine
Also known as: Emtriva, Emtri (component of Truvada, Descovy, Atripla, Biktarvy)
CAS Number: 143491-57-0
Nucleoside Reverse Transcriptase Inhibitor (NRTI)
Pharmacopeia Standards
Mechanism of Action
Emtricitabine is the 5-fluorinated analogue of lamivudine and is phosphorylated by cellular kinases to emtricitabine 5-triphosphate. The triphosphate competes with deoxycytidine triphosphate for incorporation into nascent viral DNA by HIV-1 reverse transcriptase and hepatitis B polymerase. Absence of a 3-hydroxyl on the oxathiolane ring makes incorporation an obligate chain-terminating event.
Technical Specifications
| Generic / INN Name | Emtricitabine |
| CAS Registry Number | 143491-57-0 |
| Molecular Formula | C8H10FN3O3S |
| Molecular Weight | 247.25 g/mol g/mol |
| Typical Purity | Not less than 98.0% on anhydrous basis; enantiomeric purity not less than 99.5% |
| Storage Conditions | Store below 25 degrees C in tightly closed containers protected from light and moisture. |
| Shelf Life | 48 months from date of manufacture in original sealed packing |
| Category | Antiretrovirals (HIV) |
Specifications are indicative and intended for sourcing reference only. Always confirm against the supplier's Certificate of Analysis and the applicable pharmacopeial monograph before issuing a purchase specification.
Typical Applications
Bulk API for emtricitabine and tenofovir fixed-dose combination tablets used in HIV treatment and pre-exposure prophylaxis, single-tablet regimens with bictegravir or rilpivirine, and paediatric oral solutions.
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