Ethambutol Hydrochloride
Also known as: Myambutol, Combutol, Ethide, Themibutol, Servambutol
CAS Number: 1070-11-7
Antitubercular (Ethylenediamine Derivative)
Pharmacopeia Standards
Mechanism of Action
Ethambutol inhibits the arabinosyl transferases encoded by the embCAB operon, which polymerise arabinose into the arabinogalactan and lipoarabinomannan of the mycobacterial cell wall. Loss of arabinan assembly leaves mycolic acids unanchored and increases cell wall permeability. The resulting bacteriostatic effect also potentiates the entry and activity of companion drugs in combination regimens.
Technical Specifications
| Generic / INN Name | Ethambutol Hydrochloride |
| CAS Registry Number | 1070-11-7 |
| Molecular Formula | C10H24N2O2 · 2HCl |
| Molecular Weight | 277.23 g/mol (free base 204.31 g/mol) g/mol |
| Typical Purity | 98.5% - 101.0% (on anhydrous basis, USP/BP assay) |
| Storage Conditions | Store in tightly closed, moisture-proof containers below 25 degrees C; hygroscopic, protect from humidity and light |
| Shelf Life | 48 months from date of manufacture when stored as directed |
| Category | Anti-Tubercular Agents |
Specifications are indicative and intended for sourcing reference only. Always confirm against the supplier's Certificate of Analysis and the applicable pharmacopeial monograph before issuing a purchase specification.
Typical Applications
Bulk API for 400 mg, 600 mg, 800 mg and 1000 mg ethambutol hydrochloride tablets, paediatric dispersible tablets, and the E component of HRZE and RHE fixed-dose combinations used across national TB programmes.
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