Ethionamide
Also known as: Ethiocid, Myobid, Trecator, Ethide, Etomid
CAS Number: 536-33-4
Antitubercular (Thioamide, Second-Line)
Pharmacopeia Standards
Mechanism of Action
Ethionamide is a thioamide prodrug activated by the mycobacterial monooxygenase EthA to an S-oxide and further reactive species. The activated metabolite forms an adduct with NAD that inhibits the enoyl-ACP reductase InhA, the same target as activated isoniazid. Blocking InhA arrests mycolic acid biosynthesis, though the different activating enzyme means ethionamide often retains activity against katG-mutant isoniazid-resistant strains.
Technical Specifications
| Generic / INN Name | Ethionamide |
| CAS Registry Number | 536-33-4 |
| Molecular Formula | C8H10N2S |
| Molecular Weight | 166.24 g/mol g/mol |
| Typical Purity | 98.0% - 102.0% (on dried basis, USP/BP assay) |
| Storage Conditions | Store in tightly closed, light-resistant containers below 25 degrees C in a dry, well-ventilated area; protect from light and moisture |
| Shelf Life | 48 months from date of manufacture when stored as directed |
| Category | Anti-Tubercular Agents |
Specifications are indicative and intended for sourcing reference only. Always confirm against the supplier's Certificate of Analysis and the applicable pharmacopeial monograph before issuing a purchase specification.
Typical Applications
Bulk API for 125 mg and 250 mg ethionamide tablets, film-coated and dispersible paediatric forms, used in longer multidrug-resistant tuberculosis regimens and in some leprosy and Buruli ulcer protocols.
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