Favipiravir
Also known as: Avigan, FabiFlu, Favivir, Fluguard, Coviflu
CAS Number: 259793-96-9
Antiviral (Broad-Spectrum RNA Polymerase Inhibitor)
Pharmacopeia Standards
Mechanism of Action
Favipiravir is a pyrazinecarboxamide prodrug converted intracellularly by hypoxanthine guanine phosphoribosyltransferase to favipiravir ribofuranosyl 5-triphosphate. The active form is recognised as a purine nucleotide analogue by viral RNA-dependent RNA polymerase and is incorporated into nascent viral RNA. Incorporation causes chain termination and lethal mutagenesis while sparing host DNA and RNA polymerases.
Technical Specifications
| Generic / INN Name | Favipiravir |
| CAS Registry Number | 259793-96-9 |
| Molecular Formula | C5H4FN3O2 |
| Molecular Weight | 157.10 g/mol g/mol |
| Typical Purity | Not less than 99.0% by HPLC; any individual impurity NMT 0.10% |
| Storage Conditions | Store below 30 degrees C in well-closed containers protected from light and moisture. |
| Shelf Life | 36 months from date of manufacture in original sealed packing |
| Category | Antivirals |
Specifications are indicative and intended for sourcing reference only. Always confirm against the supplier's Certificate of Analysis and the applicable pharmacopeial monograph before issuing a purchase specification.
Typical Applications
Bulk API for 200 mg and 400 mg film-coated tablets and oral suspensions, used in influenza therapy in Japan and in emergency-use antiviral formulations produced during respiratory virus outbreaks.
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