Flucloxacillin Sodium
Also known as: Floxapen, Flopen, Staphylex, Fluclox
CAS Number: 1847-24-1
Penicillinase-Resistant Isoxazolyl Penicillin (Beta-Lactam)
Pharmacopeia Standards
Mechanism of Action
The fluorinated and chlorinated phenyl isoxazolyl side chain resists hydrolysis by staphylococcal penicillinase while retaining affinity for penicillin-binding proteins. Acylation of PBP transpeptidase domains halts peptidoglycan cross-linking and triggers autolytic cell death. The fluorine substitution improves oral absorption and tissue penetration compared with cloxacillin.
Technical Specifications
| Generic / INN Name | Flucloxacillin Sodium |
| CAS Registry Number | 1847-24-1 |
| Molecular Formula | C19H16ClFN3NaO5S |
| Molecular Weight | 475.85 g/mol (anhydrous); 493.87 g/mol (monohydrate) g/mol |
| Typical Purity | NLT 95.0% and NMT 101.0% (anhydrous basis) per EP; water content 3.0-4.5% for the monohydrate |
| Storage Conditions | Store below 25 C in airtight, light-resistant containers; protect from moisture. |
| Shelf Life | 36 months for non-sterile grade; 24 months for sterile grade |
| Category | Penicillins |
Specifications are indicative and intended for sourcing reference only. Always confirm against the supplier's Certificate of Analysis and the applicable pharmacopeial monograph before issuing a purchase specification.
Typical Applications
Oral capsules and suspensions; sterile powder for intravenous and intramuscular injection; bone and joint infection product lines in EU and Commonwealth markets.
Manufacturers (0+)
View all →Do you manufacture Flucloxacillin Sodium? Add your free listing and reach global buyers.
Add listing — FreeCan you supply Flucloxacillin Sodium? List as an authorised distributor or export house.
Register as traderEarn commission by connecting buyers with verified API suppliers. Free to join.
Become an agent