Flucytosine
Also known as: Ancobon, Ancotil, Flucytosine Tablets, Cytoflu
CAS Number: 2022-85-7
Fluorinated pyrimidine antifungal — systemic
Pharmacopeia Standards
Mechanism of Action
Flucytosine is taken into fungal cells by cytosine permease and deaminated by fungal cytosine deaminase to 5-fluorouracil, an enzyme mammalian cells largely lack. The metabolite is converted to 5-fluorouridine triphosphate, which is misincorporated into fungal RNA and disrupts protein synthesis, and to 5-fluorodeoxyuridine monophosphate, which inhibits thymidylate synthase and blocks DNA replication. Rapid emergence of resistance means it is used in combination, classically with amphotericin B.
Technical Specifications
| Generic / INN Name | Flucytosine |
| CAS Registry Number | 2022-85-7 |
| Molecular Formula | C4H4FN3O |
| Molecular Weight | 129.09 g/mol |
| Typical Purity | 98.5–101.0% (on dried basis) |
| Storage Conditions | Store below 25°C in tightly closed, light-resistant containers in a dry place; protect from light |
| Shelf Life | 48 months from date of manufacture |
| Category | Antifungals |
Specifications are indicative and intended for sourcing reference only. Always confirm against the supplier's Certificate of Analysis and the applicable pharmacopeial monograph before issuing a purchase specification.
Typical Applications
Cryptococcal meningitis in combination with amphotericin B, serious systemic candidiasis, chromoblastomycosis, candidal urinary tract infection
Manufacturers (0+)
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