Fosfomycin Trometamol
Also known as: Monurol, Monuril, Fosfocina, Fosmicin, Uphos
CAS Number: 78964-85-9
Phosphonic acid antibacterial (urinary)
Pharmacopeia Standards
Mechanism of Action
Fosfomycin is a phosphoenolpyruvate analogue that enters bacteria through the glycerophosphate and hexose phosphate transport systems and irreversibly inhibits MurA, the enolpyruvyl transferase that catalyses the first committed step of peptidoglycan synthesis. Blocking cell wall assembly at this earliest stage gives bactericidal activity and no cross-resistance with beta-lactams, aminoglycosides or quinolones. The trometamol salt provides the oral bioavailability and urinary concentrations needed for single-dose therapy.
Technical Specifications
| Generic / INN Name | Fosfomycin Trometamol |
| CAS Registry Number | 78964-85-9 |
| Molecular Formula | C3H7O4P . C4H11NO3 (C7H18NO7P) |
| Molecular Weight | 259.19 g/mol g/mol |
| Typical Purity | 95.0-102.0% on anhydrous basis (EP); fosfomycin content per monograph, water NMT 0.5% |
| Storage Conditions | Store below 25 C in hermetically sealed, moisture-proof containers; highly hygroscopic, handle under controlled low humidity |
| Shelf Life | 36 months from date of manufacture in intact moisture-barrier packing |
| Category | Urinary Antiseptics |
Specifications are indicative and intended for sourcing reference only. Always confirm against the supplier's Certificate of Analysis and the applicable pharmacopeial monograph before issuing a purchase specification.
Typical Applications
Single-dose 3 g oral sachets and granules for uncomplicated urinary tract infection and for surgical or transrectal biopsy prophylaxis; increasingly used empirically against ESBL-producing uropathogens.
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