Furazolidone
Also known as: Furoxone, Dependal-M, Furoxil, Neftin
CAS Number: 67-45-8
Nitrofuran antibacterial and antiprotozoal
Pharmacopeia Standards
Mechanism of Action
Furazolidone is reduced by bacterial nitroreductases to reactive intermediates that cross-link DNA and inactivate multiple enzyme systems, producing a broad bactericidal effect against enteric Gram-negative organisms, Giardia and Trichomonas. It also acts as a weak reversible monoamine oxidase inhibitor at therapeutic exposures, which underlies its dietary and drug interaction cautions. Resistance development is slow because several bacterial targets are hit at once.
Technical Specifications
| Generic / INN Name | Furazolidone |
| CAS Registry Number | 67-45-8 |
| Molecular Formula | C8H7N3O5 |
| Molecular Weight | 225.16 g/mol g/mol |
| Typical Purity | 97.0-102.0% on dried basis; related nitrofurans within monograph limits |
| Storage Conditions | Store in tightly closed light-resistant containers below 25 C; protect from light and moisture |
| Shelf Life | 36 months from date of manufacture |
| Category | Nitrofurans |
Specifications are indicative and intended for sourcing reference only. Always confirm against the supplier's Certificate of Analysis and the applicable pharmacopeial monograph before issuing a purchase specification.
Typical Applications
Oral tablets and suspensions for bacterial diarrhoea, giardiasis and cholera in LMIC markets, and historically as a component of Helicobacter pylori eradication regimens in China and South America.
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