Griseofulvin
Also known as: Grisovin FP, Gris-PEG, Fulcin, Grifulvin V, Walavin
CAS Number: 126-07-8
Benzofuran antifungal antibiotic — systemic, dermatophyte-specific
Pharmacopeia Standards
Mechanism of Action
Griseofulvin binds fungal tubulin and associated microtubule-associated proteins, disrupting mitotic spindle assembly and arresting the dermatophyte cell cycle in metaphase. It also interferes with microtubule-dependent transport of cell wall precursors, producing distorted, stunted hyphae. Because it deposits preferentially in newly formed keratin, activity is confined to keratinised tissue and to dermatophytes only.
Technical Specifications
| Generic / INN Name | Griseofulvin |
| CAS Registry Number | 126-07-8 |
| Molecular Formula | C17H17ClO6 |
| Molecular Weight | 352.77 g/mol |
| Typical Purity | 97.0–102.0% (on dried basis) |
| Storage Conditions | Store below 25°C in well-closed, light-resistant containers in a dry place; protect from light |
| Shelf Life | 60 months from date of manufacture |
| Category | Antifungals |
Specifications are indicative and intended for sourcing reference only. Always confirm against the supplier's Certificate of Analysis and the applicable pharmacopeial monograph before issuing a purchase specification.
Typical Applications
Tinea capitis, particularly in children, tinea corporis, cruris, pedis and barbae unresponsive to topical therapy, tinea unguium
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