Hydroxychloroquine Sulfate
Also known as: Plaquenil, HCQS, Hydroquin, Oxcq, Quensyl, Zy-Q
CAS Number: 747-36-4
Antimalarial / Disease-Modifying Antirheumatic (4-Aminoquinoline)
Pharmacopeia Standards
Mechanism of Action
Hydroxychloroquine shares chloroquine’s haem-polymerisation blockade in the parasite food vacuole, with an added hydroxyl group that improves its therapeutic index. In autoimmune disease it raises endosomal pH, impairing Toll-like receptor 7 and 9 signalling and antigen processing, which dampens interferon and cytokine output. This immunomodulatory action, not the antimalarial one, now accounts for the great majority of global consumption.
Technical Specifications
| Generic / INN Name | Hydroxychloroquine Sulfate |
| CAS Registry Number | 747-36-4 |
| Molecular Formula | C18H26ClN3O · H2SO4 |
| Molecular Weight | 433.95 g/mol g/mol |
| Typical Purity | Not less than 98.5% (assay), on the dried basis |
| Storage Conditions | Store in tight, light-resistant containers below 30°C; protect from moisture due to hygroscopicity |
| Shelf Life | 48–60 months in original sealed packaging |
| Category | Antimalarials |
Specifications are indicative and intended for sourcing reference only. Always confirm against the supplier's Certificate of Analysis and the applicable pharmacopeial monograph before issuing a purchase specification.
Typical Applications
Film-coated tablets for rheumatoid arthritis, systemic and discoid lupus erythematosus, and malaria prophylaxis and treatment in sensitive strains.
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