Isavuconazonium Sulfate
Also known as: Cresemba
CAS Number: 946075-13-4
Triazole antifungal prodrug — systemic, extended spectrum
Mechanism of Action
Isavuconazonium sulfate is a water-soluble prodrug rapidly cleaved by plasma butyrylcholinesterase to release the active triazole isavuconazole. Isavuconazole binds fungal CYP51 and blocks 14-alpha-demethylation of lanosterol, depleting ergosterol and destabilising the fungal membrane. The prodrug design avoids the cyclodextrin vehicle required by voriconazole and posaconazole injections, which is relevant in renal impairment.
Technical Specifications
| Generic / INN Name | Isavuconazonium Sulfate |
| CAS Registry Number | 946075-13-4 |
| Molecular Formula | C35H36F2N8O9S2 |
| Molecular Weight | 814.84 g/mol |
| Typical Purity | 98.0–102.0% (on anhydrous basis) |
| Storage Conditions | Store at 2–8°C in tightly closed, light-resistant containers under nitrogen; protect from moisture and heat |
| Shelf Life | 24 months from date of manufacture |
| Category | Antifungals |
Specifications are indicative and intended for sourcing reference only. Always confirm against the supplier's Certificate of Analysis and the applicable pharmacopeial monograph before issuing a purchase specification.
Typical Applications
Invasive aspergillosis, invasive mucormycosis, salvage therapy for rare moulds in patients intolerant of other triazoles
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