Kanamycin Sulfate
Also known as: Kantrex, Kanamac, Kanacyn, Kanrid
CAS Number: 25389-94-0
Antitubercular / Aminoglycoside Antibiotic
Pharmacopeia Standards
Mechanism of Action
Kanamycin binds the 16S ribosomal RNA of the 30S ribosomal subunit and induces misreading of the genetic code during translation. Incorporation of incorrect amino acids yields non-functional proteins and compromises membrane integrity, allowing further drug uptake in a self-amplifying cycle. The result is rapid concentration-dependent bactericidal activity against extracellular mycobacteria and many aerobic Gram-negative organisms.
Technical Specifications
| Generic / INN Name | Kanamycin Sulfate |
| CAS Registry Number | 25389-94-0 |
| Molecular Formula | C18H36N4O11 · H2SO4 |
| Molecular Weight | 582.58 g/mol (free base 484.50 g/mol) g/mol |
| Typical Purity | Not less than 750 mcg of kanamycin per mg (on dried basis, USP potency) |
| Storage Conditions | Store below 25 degrees C in tightly closed, moisture-proof containers; hygroscopic, protect from light and humidity |
| Shelf Life | 36 months from date of manufacture when stored as directed |
| Category | Anti-Tubercular Agents |
Specifications are indicative and intended for sourcing reference only. Always confirm against the supplier's Certificate of Analysis and the applicable pharmacopeial monograph before issuing a purchase specification.
Typical Applications
Bulk sterile and non-sterile API for kanamycin sulfate injection (500 mg, 1 g vials) used in second-line tuberculosis regimens, plus ophthalmic preparations, veterinary products and laboratory selection media.
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