Luliconazole
Also known as: Luzu, Lulicon, Lulibet, Luliforce, Lulifin, Fungikos
CAS Number: 187164-19-8
Imidazole antifungal — topical, ketene dithioacetal
Pharmacopeia Standards
Mechanism of Action
Luliconazole inhibits fungal lanosterol 14-alpha-demethylase and thereby ergosterol biosynthesis, but its R-enantiomer binds with exceptional potency, giving minimum inhibitory concentrations against dermatophytes an order of magnitude below older imidazoles. The ketene dithioacetal moiety appears to contribute additional membrane-level activity. Its high keratin affinity produces prolonged retention in the stratum corneum, allowing short once-daily courses.
Technical Specifications
| Generic / INN Name | Luliconazole |
| CAS Registry Number | 187164-19-8 |
| Molecular Formula | C14H9Cl2N3S2 |
| Molecular Weight | 354.28 g/mol |
| Typical Purity | 98.0–102.0% (on anhydrous basis); S-enantiomer not more than 1.0% |
| Storage Conditions | Store at 2–8°C in tightly closed, light-resistant containers under nitrogen; protect from light and moisture |
| Shelf Life | 36 months from date of manufacture |
| Category | Antifungals |
Specifications are indicative and intended for sourcing reference only. Always confirm against the supplier's Certificate of Analysis and the applicable pharmacopeial monograph before issuing a purchase specification.
Typical Applications
Tinea pedis interdigitalis, tinea cruris and corporis, onychomycosis as topical solution, cutaneous candidiasis, pityriasis versicolor
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