Lumefantrine
Also known as: Coartem (with artemether), Riamet, Lumet, Lumerax, Combither
CAS Number: 82186-77-4
Antimalarial (Aryl Amino Alcohol)
Pharmacopeia Standards
Mechanism of Action
Lumefantrine is thought to interfere with the polymerisation of haem into inert haemozoin inside the parasite food vacuole, allowing cytotoxic free haem and reactive oxygen species to accumulate. Its long elimination half-life clears residual parasitaemia after the short-acting artemisinin partner has collapsed parasite biomass. This partner-drug tail is what protects the artemisinin component from resistance selection.
Technical Specifications
| Generic / INN Name | Lumefantrine |
| CAS Registry Number | 82186-77-4 |
| Molecular Formula | C30H32Cl3NO |
| Molecular Weight | 528.94 g/mol g/mol |
| Typical Purity | Not less than 98.5% (HPLC), on the anhydrous basis |
| Storage Conditions | Store below 30°C in well-closed containers; protect from light and moisture |
| Shelf Life | 48–60 months in original sealed packaging |
| Category | Antimalarials |
Specifications are indicative and intended for sourcing reference only. Always confirm against the supplier's Certificate of Analysis and the applicable pharmacopeial monograph before issuing a purchase specification.
Typical Applications
Fixed-dose artemether-lumefantrine tablets and dispersible paediatric tablets, the single highest-volume ACT presentation worldwide.
Manufacturers (0+)
View all →Do you manufacture Lumefantrine? Add your free listing and reach global buyers.
Add listing — FreeCan you supply Lumefantrine? List as an authorised distributor or export house.
Register as traderEarn commission by connecting buyers with verified API suppliers. Free to join.
Become an agent