Mebendazole
Also known as: Vermox, Emverm, Mebex, Wormin, Antiox, Ovex
CAS Number: 31431-39-7
Broad-Spectrum Anthelmintic (Benzimidazole Carbamate)
Pharmacopeia Standards
Mechanism of Action
Mebendazole binds parasite beta-tubulin with high selectivity and blocks microtubule assembly in the helminth gut cell. The resulting failure of glucose absorption and vesicular transport depletes worm glycogen stores and ATP production, causing paralysis and expulsion. Very low systemic absorption keeps the drug concentrated in the intestinal lumen, which suits it to intestinal nematode infections.
Technical Specifications
| Generic / INN Name | Mebendazole |
| CAS Registry Number | 31431-39-7 |
| Molecular Formula | C16H13N3O3 |
| Molecular Weight | 295.29 g/mol g/mol |
| Typical Purity | Not less than 98.0% (assay), on the dried basis; polymorph C confirmed by XRD |
| Storage Conditions | Store in well-closed, light-resistant containers below 30°C; protect from moisture |
| Shelf Life | 60 months in original sealed packaging |
| Category | Anthelmintics |
Specifications are indicative and intended for sourcing reference only. Always confirm against the supplier's Certificate of Analysis and the applicable pharmacopeial monograph before issuing a purchase specification.
Typical Applications
Chewable tablets, dispersible tablets and oral suspensions for pinworm, roundworm, whipworm and hookworm; combination deworming products; veterinary formulations.
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