Mefloquine Hydrochloride
Also known as: Lariam, Mephaquin, Mefliam, Larimef, Mefax
CAS Number: 51773-92-3
Antimalarial (Quinoline Methanol)
Pharmacopeia Standards
Mechanism of Action
Mefloquine is a 4-quinoline methanol that concentrates in the parasite food vacuole and is believed to disrupt haem detoxification and to interfere with parasite endocytosis of host cytosol. It also inhibits the 80S ribosome, contributing a second point of attack. Its long elimination half-life makes it an effective partner drug and a once-weekly prophylactic option where the resistance picture allows.
Technical Specifications
| Generic / INN Name | Mefloquine Hydrochloride |
| CAS Registry Number | 51773-92-3 |
| Molecular Formula | C17H16F6N2O · HCl |
| Molecular Weight | 414.77 g/mol g/mol |
| Typical Purity | Not less than 99.0% (HPLC), on the anhydrous basis |
| Storage Conditions | Store in tight, light-resistant containers below 30°C; protect from moisture |
| Shelf Life | 48 months in original sealed packaging |
| Category | Antimalarials |
Specifications are indicative and intended for sourcing reference only. Always confirm against the supplier's Certificate of Analysis and the applicable pharmacopeial monograph before issuing a purchase specification.
Typical Applications
Tablets for malaria prophylaxis and treatment; fixed-dose artesunate-mefloquine combination tablets used extensively in the Greater Mekong Subregion and South America.
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