Methenamine Hippurate
Also known as: Hiprex, Urex, Haiprex, Methenamine Hippurate Tablets
CAS Number: 5714-73-8
Urinary antiseptic (non-antibiotic)
Pharmacopeia Standards
Mechanism of Action
Methenamine is excreted unchanged into urine where, at pH below approximately 5.5, it hydrolyses to formaldehyde and ammonia. The liberated formaldehyde denatures bacterial proteins and nucleic acids non-specifically, so no meaningful bacterial resistance develops even after years of continuous use. The hippurate counter-ion contributes by helping acidify the urine and sustain the hydrolysis reaction.
Technical Specifications
| Generic / INN Name | Methenamine Hippurate |
| CAS Registry Number | 5714-73-8 |
| Molecular Formula | C6H12N4 . C9H9NO3 (C15H21N5O3) |
| Molecular Weight | 319.36 g/mol g/mol |
| Typical Purity | 98.0-102.0% on dried basis (USP); free formaldehyde within monograph limit |
| Storage Conditions | Store in tight containers below 25 C; hygroscopic, protect from moisture and avoid contact with acids |
| Shelf Life | 36 months from date of manufacture in sealed moisture-barrier packing |
| Category | Urinary Antiseptics |
Specifications are indicative and intended for sourcing reference only. Always confirm against the supplier's Certificate of Analysis and the applicable pharmacopeial monograph before issuing a purchase specification.
Typical Applications
Oral tablets for long-term prophylaxis of recurrent urinary tract infection, particularly in women with frequent recurrences and in patients where repeated antibiotic courses are being avoided.
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