Metronidazole

Also known as: Flagyl, Metrogyl, Metronid, Rozex

CAS Number: 443-48-1

Nitroimidazole antibiotic — anaerobic and antiprotozoal agent

Pharmacopeia Standards

USPBPIPEP

Mechanism of Action

Prodrug activated by ferredoxin or flavodoxin electron transport proteins in anaerobic organisms. Reduced nitroso radical intermediate damages DNA by strand breakage and helix destabilization. Active only in low oxygen tension environments. Spectrum: obligate anaerobes (Bacteroides, Clostridium including C. difficile), protozoa (Trichomonas, Giardia, Entamoeba histolytica). No activity against aerobic or facultative organisms alone.

Technical Specifications

Generic / INN Name	Metronidazole
CAS Registry Number	443-48-1
Molecular Formula	C6H9N3O3
Molecular Weight	171.16 g/mol
Typical Purity	99.0–101.0%
Storage Conditions	Store below 25°C, protected from light
Shelf Life	36 months from date of manufacture
Category	Nitroimidazoles

Specifications are indicative and intended for sourcing reference only. Always confirm against the supplier's Certificate of Analysis and the applicable pharmacopeial monograph before issuing a purchase specification.

Typical Applications

C. difficile infections (first-line for mild-moderate), bacterial vaginosis, trichomoniasis (first-line, single-dose 2g), giardiasis, amoebiasis (intestinal and hepatic), intra-abdominal infections (always with aerobic coverage), periodontal/dental infections, H. pylori eradication (triple/quadruple therapy), pelvic inflammatory disease, prophylaxis in colorectal surgery.