Mezlocillin Sodium
Also known as: Mezlin, Baypen, Optocillin (in combination)
CAS Number: 59798-30-0
Ureidopenicillin, Extended-Spectrum (Beta-Lactam)
Pharmacopeia Standards
Mechanism of Action
Mezlocillin is an acylureido penicillin whose imidazolidinyl-urea side chain enhances penetration of the Gram-negative outer membrane and affinity for penicillin-binding protein 3. Inhibition of PBP3 blocks septal peptidoglycan synthesis, producing filamentous cells that subsequently lyse. Its spectrum covers many Enterobacterales, Pseudomonas aeruginosa and Bacteroides species, although it remains susceptible to most beta-lactamases.
Technical Specifications
| Generic / INN Name | Mezlocillin Sodium |
| CAS Registry Number | 59798-30-0 |
| Molecular Formula | C21H24N5NaO8S2 |
| Molecular Weight | 561.56 g/mol g/mol |
| Typical Purity | NLT 85.0% mezlocillin on the anhydrous basis; endotoxin NMT 0.10 IU/mg |
| Storage Conditions | Store below 25 C in tight, light-resistant containers under nitrogen; protect from moisture. |
| Shelf Life | 24 months for sterile grade in original sealed packaging |
| Category | Penicillins |
Specifications are indicative and intended for sourcing reference only. Always confirm against the supplier's Certificate of Analysis and the applicable pharmacopeial monograph before issuing a purchase specification.
Typical Applications
Sterile powder for injection and infusion; hospital intra-abdominal and gynaecological infection formularies; combination products with sulbactam in Chinese and Middle Eastern markets.
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