Minocycline Hydrochloride
Also known as: Minocin, Solodyn, Dynacin, Ximino, Cyclimycin
CAS Number: 13614-98-7
Tetracycline Antibacterial
Pharmacopeia Standards
Mechanism of Action
Minocycline binds reversibly to the 30S ribosomal subunit and blocks attachment of aminoacyl-tRNA to the ribosomal A site, halting peptide chain elongation. Its 7-dimethylamino group and absence of a C6 hydroxyl give the highest lipophilicity of the classical tetracyclines and correspondingly strong tissue and CNS penetration. Separate anti-inflammatory and matrix metalloproteinase-inhibiting effects underpin its dermatological and periodontal use.
Technical Specifications
| Generic / INN Name | Minocycline Hydrochloride |
| CAS Registry Number | 13614-98-7 |
| Molecular Formula | C23H27N3O7 . HCl |
| Molecular Weight | 493.94 g/mol g/mol |
| Typical Purity | NLT 890 micrograms of minocycline per mg on the anhydrous basis (USP); epiminocycline NMT 1.2% |
| Storage Conditions | Store at 2-8 degrees C or below 25 degrees C in airtight light-resistant containers under nitrogen; protect from moisture |
| Shelf Life | 36-48 months from date of manufacture depending on grade and packing |
| Category | Tetracyclines |
Specifications are indicative and intended for sourcing reference only. Always confirm against the supplier's Certificate of Analysis and the applicable pharmacopeial monograph before issuing a purchase specification.
Typical Applications
Oral immediate- and extended-release tablets and capsules, sterile powder for injection, periodontal microspheres, and topical foam. Dermatology accounts for a large share of global demand.
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