Nalidixic Acid
Also known as: NegGram, Wintomylon, Nalidix, Gramoneg
CAS Number: 389-08-2
Quinolone Antibacterial (First Generation)
Pharmacopeia Standards
Mechanism of Action
Nalidixic acid inhibits the A subunit of bacterial DNA gyrase, blocking the religation step of DNA supercoiling and generating lethal double-strand breaks. As the original naphthyridone quinolone it lacks a fluorine at C6, which limits potency and tissue penetration relative to fluorinated successors. Activity is essentially confined to Gram-negative urinary pathogens.
Technical Specifications
| Generic / INN Name | Nalidixic Acid |
| CAS Registry Number | 389-08-2 |
| Molecular Formula | C12H12N2O3 |
| Molecular Weight | 232.24 g/mol g/mol |
| Typical Purity | 99.0-101.0% on the dried basis (USP/EP); total impurities NMT 0.5% |
| Storage Conditions | Store below 30 degrees C in well-closed containers, protected from light |
| Shelf Life | 60 months from date of manufacture |
| Category | Fluoroquinolones |
Specifications are indicative and intended for sourcing reference only. Always confirm against the supplier's Certificate of Analysis and the applicable pharmacopeial monograph before issuing a purchase specification.
Typical Applications
Oral tablets and suspensions for uncomplicated urinary tract indications and paediatric shigellosis in some markets. Also heavily used as a selective agent in microbiological culture media and as a synthetic reference compound.
Manufacturers (0+)
View all →Do you manufacture Nalidixic Acid? Add your free listing and reach global buyers.
Add listing — FreeCan you supply Nalidixic Acid? List as an authorised distributor or export house.
Register as traderEarn commission by connecting buyers with verified API suppliers. Free to join.
Become an agent