Netilmicin Sulfate
Also known as: Netromycin, Netira, Netilyn, Certomycin
CAS Number: 56391-57-2
Aminoglycoside Antibacterial
Pharmacopeia Standards
Mechanism of Action
Netilmicin binds the 30S ribosomal subunit and induces codon misreading and premature termination of translation, generating defective membrane proteins and lethal permeability changes. The 1-N-ethyl substitution on sisomicin sterically hinders several aminoglycoside-modifying enzymes, preserving activity against some gentamicin-resistant Gram-negative isolates. Bactericidal action is concentration dependent with a prolonged post-antibiotic effect.
Technical Specifications
| Generic / INN Name | Netilmicin Sulfate |
| CAS Registry Number | 56391-57-2 |
| Molecular Formula | C42H92N10O34S5 (2 C21H41N5O7 . 5H2SO4) |
| Molecular Weight | 1441.55 g/mol g/mol |
| Typical Purity | NLT 650 IU of netilmicin per mg on the anhydrous basis (EP); sulfate content and related aminoglycosides within monograph limits |
| Storage Conditions | Store at 2-8 degrees C or below 25 degrees C in airtight containers protected from light and moisture; sterile grade under aseptic control |
| Shelf Life | 36 months from date of manufacture |
| Category | Aminoglycosides |
Specifications are indicative and intended for sourcing reference only. Always confirm against the supplier's Certificate of Analysis and the applicable pharmacopeial monograph before issuing a purchase specification.
Typical Applications
Sterile solutions for intramuscular and intravenous injection, and ophthalmic preparations in some markets. Sterile-grade API is the dominant commercial form.
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