Nevirapine
Also known as: Viramune, Nevimune, Nevipan (component of Duovir-N, Triomune)
CAS Number: 129618-40-2
Non-Nucleoside Reverse Transcriptase Inhibitor (NNRTI)
Pharmacopeia Standards
Mechanism of Action
Nevirapine is a dipyridodiazepinone that binds directly to the non-nucleoside allosteric pocket of HIV-1 reverse transcriptase about ten angstroms from the polymerase active site. The resulting conformational distortion of the catalytic aspartate triad blocks RNA-dependent and DNA-dependent DNA polymerase activity without competing with nucleoside triphosphates. Activity is restricted to HIV-1, and single point mutations such as K103N or Y181C confer high-level resistance.
Technical Specifications
| Generic / INN Name | Nevirapine |
| CAS Registry Number | 129618-40-2 |
| Molecular Formula | C15H14N6O |
| Molecular Weight | 266.30 g/mol g/mol |
| Typical Purity | Not less than 98.0% on anhydrous basis (USP/IP) |
| Storage Conditions | Store below 30 degrees C in well-closed containers protected from light; avoid excessive humidity. |
| Shelf Life | 60 months from date of manufacture in original sealed packing |
| Category | Antiretrovirals (HIV) |
Specifications are indicative and intended for sourcing reference only. Always confirm against the supplier's Certificate of Analysis and the applicable pharmacopeial monograph before issuing a purchase specification.
Typical Applications
Bulk API for immediate-release and extended-release tablets, paediatric oral suspensions, dispersible paediatric tablets, and triple fixed-dose combinations with stavudine or zidovudine plus lamivudine.
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