Nitroxoline
Also known as: Nitroxolin forte, Nibiol, Uro-Nitroxolin, Noxyflex, 5-NOK
CAS Number: 4008-48-4
Hydroxyquinoline urinary antibacterial
Pharmacopeia Standards
Mechanism of Action
Nitroxoline is an 8-hydroxyquinoline that chelates divalent cations, principally zinc, magnesium and iron, stripping the metal cofactors that bacteria need for metalloenzyme function and for biofilm matrix stability. This metal-chelating action inhibits RNA polymerase activity and prevents adhesion and biofilm formation on urothelium and catheter surfaces, which distinguishes it from conventional urinary antibiotics. It reaches high concentrations in urine while producing little systemic exposure.
Technical Specifications
| Generic / INN Name | Nitroxoline |
| CAS Registry Number | 4008-48-4 |
| Molecular Formula | C9H6N2O3 |
| Molecular Weight | 190.16 g/mol g/mol |
| Typical Purity | 98.5-101.0% on dried basis (EP); 7-nitro isomer and related substances within monograph limits |
| Storage Conditions | Store in well-closed light-resistant containers at 15-25 C, protect from light and moisture |
| Shelf Life | 48 months from date of manufacture |
| Category | Urinary Antiseptics |
Specifications are indicative and intended for sourcing reference only. Always confirm against the supplier's Certificate of Analysis and the applicable pharmacopeial monograph before issuing a purchase specification.
Typical Applications
Oral capsules and tablets for acute and recurrent uncomplicated urinary tract infection and for long-term prophylaxis, marketed mainly in Germany, Central and Eastern Europe, Russia and China.
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