Oritavancin Diphosphate
Also known as: Orbactiv, Kimyrsa, Tenkasi
CAS Number: 192564-14-0
Lipoglycopeptide Antibacterial (Reserve)
Mechanism of Action
Oritavancin acts by three mechanisms: it binds the D-alanyl-D-alanine terminus to inhibit transglycosylation, binds the pentaglycyl bridge segment of peptidoglycan to inhibit transpeptidation, and disrupts bacterial membrane integrity through its 4-prime-chlorobiphenylmethyl side chain. The additional binding site and membrane activity preserve killing against vanA vancomycin-resistant enterococci. The result is rapid concentration-dependent bactericidal activity with a very long terminal half-life.
Technical Specifications
| Generic / INN Name | Oritavancin Diphosphate |
| CAS Registry Number | 192564-14-0 |
| Molecular Formula | C86H97Cl3N10O26 . 2H3PO4 |
| Molecular Weight | 1989.09 g/mol g/mol |
| Typical Purity | NLT 95.0% by HPLC on the free base anhydrous basis; phosphate content consistent with the diphosphate; endotoxin NMT 0.10 EU/mg |
| Storage Conditions | Store at 2-8 degrees C in airtight light-resistant containers under nitrogen and aseptic control; hygroscopic |
| Shelf Life | 24 months from date of manufacture under refrigerated storage |
| Category | Glycopeptides |
Specifications are indicative and intended for sourcing reference only. Always confirm against the supplier's Certificate of Analysis and the applicable pharmacopeial monograph before issuing a purchase specification.
Typical Applications
Lyophilised powder for intravenous infusion for acute bacterial skin and skin structure infections, given as a single dose. Sterile-grade API only, supplied as the diphosphate salt for solubility and stability.
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