Oxacillin Sodium
Also known as: Bactocill, Prostaphlin, Oxacillin for Injection
CAS Number: 1173-88-2
Penicillinase-Resistant Isoxazolyl Penicillin (Beta-Lactam)
Pharmacopeia Standards
Mechanism of Action
Oxacillin was the first isoxazolyl penicillin, using an unsubstituted phenyl isoxazolyl side chain to block access of staphylococcal penicillinase to the beta-lactam carbonyl. The surviving ring acylates penicillin-binding proteins and arrests peptidoglycan transpeptidation. Susceptibility to oxacillin is the defining laboratory criterion separating methicillin-susceptible from methicillin-resistant Staphylococcus aureus.
Technical Specifications
| Generic / INN Name | Oxacillin Sodium |
| CAS Registry Number | 1173-88-2 |
| Molecular Formula | C19H18N3NaO5S |
| Molecular Weight | 423.41 g/mol (anhydrous); 441.43 g/mol (monohydrate) g/mol |
| Typical Purity | NLT 90.0% oxacillin sodium on the anhydrous basis; sterile grade endotoxin NMT 0.13 IU/mg |
| Storage Conditions | Store below 25 C in tight, light-resistant containers under low humidity; sterile grade under nitrogen in validated double-bag systems. |
| Shelf Life | 36 months for non-sterile grade; 24 months for sterile grade |
| Category | Penicillins |
Specifications are indicative and intended for sourcing reference only. Always confirm against the supplier's Certificate of Analysis and the applicable pharmacopeial monograph before issuing a purchase specification.
Typical Applications
Sterile powder for injection in 250 mg to 10 g vials; antimicrobial susceptibility testing discs, strips and reference standards; hospital anti-staphylococcal formularies.
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