Oxytetracycline Hydrochloride
Also known as: Terramycin, Oxymycin, Liquamycin, Engemycin, Tetravet
CAS Number: 2058-46-0
Tetracycline Antibacterial
Pharmacopeia Standards
Mechanism of Action
Oxytetracycline binds the 30S ribosomal subunit and prevents aminoacyl-tRNA from docking at the A site, arresting protein synthesis in a bacteriostatic manner. Active uptake into Gram-negative cells via porins and energy-dependent transport gives selective accumulation in bacteria over mammalian cells. The C5 hydroxyl distinguishes it from tetracycline and modestly alters its chelation and tissue distribution.
Technical Specifications
| Generic / INN Name | Oxytetracycline Hydrochloride |
| CAS Registry Number | 2058-46-0 |
| Molecular Formula | C22H24N2O9 . HCl |
| Molecular Weight | 496.89 g/mol g/mol |
| Typical Purity | NLT 835 micrograms of oxytetracycline per mg on the anhydrous basis (USP); 4-epi-oxytetracycline and tetracycline within monograph limits |
| Storage Conditions | Store below 25 degrees C in airtight light-resistant containers, protected from moisture; avoid contact with metals |
| Shelf Life | 36-48 months from date of manufacture depending on grade |
| Category | Tetracyclines |
Specifications are indicative and intended for sourcing reference only. Always confirm against the supplier's Certificate of Analysis and the applicable pharmacopeial monograph before issuing a purchase specification.
Typical Applications
Human oral capsules and ophthalmic and dermatological ointments, and very large veterinary volumes as injectable long-acting solutions, water-soluble powders, intramammary preparations and medicated feed premixes.
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